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Ritz, et al

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712,713 Ischemic stroke patients experience a decline in their ability to perform daily activities and overall cognitive function, with a 157% increase in dementia

M.GarwoodC

Orthogonal validation of NMR fragment hit 27 Encouraged by the relatively high binding affinity of compound 27 compared to expectations for fragments, we synthesised a series of analogues to explore the effect of modifying both the sulfonic acid and the ethoxy substituents on binding affinity (Table 1)